Trump’s timely evangelical appeal
A clue into treatments for triple negative breast cancer
President Trump ad-
dressed this year’s annual
Values Voters Summit in
Washington, D.C. He is the
first sitting U.S. president to
do so.
The Values Voters Sum-
mit is hosted by the Family
Research Council, an orga-
nization whose mission is
addressing public policy
and culture from a Christian
point of view. My organiza-
tion CURE works closely
with FRC and I have been a
regular speaker at this Sum-
mit for years.
Its base is largely evan-
gelical Christians, and this
is why President Trump
deemed it appropriate to ap-
pear.
Eighty-one percent of
white evangelicals voted for
Trump in 2016, the highest
percentage of evangelical
support for any Republican
in the last four presidential
elections.
According to the Pew Re-
search Center, 36 percent of
the electorate self-identifies
as evangelical Christian, so
it’s indicative of Trump’s
strong political instincts that
he has gone out to actively
engage this important and
significant base of support.
It’s my sense that Trump’s
relationship with evangeli-
cals is growing stronger.
During the election, he
was by and large an un-
known quantity to these
folks. And given his history,
there was good reason for
evangelicals to have reser-
vations in their support.
But there was one is-
sue critical enough to drive
their support — replacing
Supreme Court Associate
Justice Antonin Scalia with
another judge of equally
stellar conservative creden-
tials.
Trump, as he reminded
the audience in his Values
Voters address, has not let
them down with his ap-
pointment of new Associ-
ate Justice Neil Gorsuch to
replace Scalia, and a string
of equally impressive other
conservative lower court ap-
pointments.
However, since the elec-
tion, Trump has taken ac-
tions that
have ex-
p a n d e d ,
b r o a d -
ened and
shored up
his rela-
tions with
this evan-
g e l i c a l
base.
He be-
gan by re-
i ns t a t i ng
the Mex-
ico City policy, first initi-
ated by President Reagan
in 1984 and later rescinded
by President Obama, which
prohibits U.S foreign aid
from being used by overseas
organizations to perform
abortions.
He recently opened the
door for employers with re-
ligious objections to bail out
of the Obamacare require-
ment of providing birth con-
trol devices and pills to em-
ployees free of charge.
Trump’s clear support of
Israel — he was also the
first sitting American presi-
dent to visit Israel in the ear-
ly months of his presidency
and to visit the Western Wall
in the old city of Jerusalem
— appeals to Evangelicals.
And the recent announce-
ment by the Trump admin-
istration that the United
States will withdraw from
the anti-American, anti-Is-
rael United Nations agency
UNESCO.
As the culture war in
America rages, Trump
understands the political
dividends to be gained by
clearly supporting tradi-
tional Christian values and
unabashed American patrio-
tism.
There has not been a time
more important in recent
history to take on these mat-
ters, and President Trump is
stepping up.
Most in America’s evan-
gelical communities, includ-
ing substantial numbers of
black evangelicals, were ap-
palled when Obama moved
to support LGBTQ secular-
ism, even lighting up the
White House in rainbow flag
colors. Equally appalling to
evangelicals was Obama
agreeing to be the first sit-
ting American president to
address the annual meet-
ing of Planned Parenthood,
America’s largest abortion
provider, concluding his ad-
dress to these abortionists
with, “God bless you.”
In recent Gallup polling,
in response to the ques-
tion if government “should
promote traditional values
in our society,” 66 percent
of Republicans versus 30
percent of Democrats say
“yes.”
Addressing this conserva-
tive Republican base is what
Trump took on in his Values
Voters speech. He conveyed
what our Founding Fathers
understood — that a free
society needs morality and
morality needs religion, a
nation under God.
While liberals are tiptoe-
ing around the underlying
truths conveyed by Trump
at the Values Voters sum-
mit, millions of Americans
across all ethnic lines are
listening to the president’s
message and are ready to
hear more.
- Star Parker is a syndi-
cated columnist for Cre-
ators Syndicate, Inc.
Tuesday, October 24, 2017
A-4
Corker is a
profile in courage
Let’s get one thing straight about this
Twitter-fueled squabble between President
Donald Trump and Senator Bob Corker.
Members of Congress do not work for
the president of the United States.
They do not pledge an oath of loyalty to
the president of United States.
The only oath they take is to the U.S.
Constitution, which means they serve the
people.
The role of Congress is to keep checks
and balances on the executive branch, not
to curry favor with the president, regard-
less of how much he demands obeisance.
The people elect members of Congress
to be independent, to represent their inter-
ests and to make tough decisions that may
not always be popular — for the good of
the country.
The Trump-Corker scrap has been a
terrible distraction. It started as a series of
tweets last Sunday by the president, who
showed once again how he has no control
over his impulses.
In seeking to humiliate Corker, a fel-
low Republican who is choosing to retire
rather than run for re-election in 2018,
Trump may not have expected a response
back because Corker is typically above the
fray.
But Corker, R-Chattanooga, chose to
respond with a snarky comeback. Boy, did
that start a firestorm.
Former White House senior adviser Ste-
phen Bannon on Monday called on Corker
to resign.
That is just ludicrous. Criticizing an
elected official is not a fireable offense,
otherwise Trump should have resigned
long ago.
Congressman Diane Black, R-Gallatin,
who is running for Tennessee governor,
used Corker’s description of the White
House as an “adult day care center” to
describe the Senate.
No, the Senate is not an adult daycare
center, it is a constitutionally delibera-
tive body, which should take its time to
pass legislation and not hastily pass bills
without the opportunity for the public to
understand what is going on.
Meanwhile, Corker’s spokeswoman said
any notion that the senator would resign
was “ridiculous.”
Corker should resist efforts to oust him
before the end of his term in January 2019.
If he needs inspiration, he (and his col-
leagues) should re-read John F. Kennedy’s
Pulitzer Prize winning book “Profiles in
Courage” about eight courageous senators
who chose to act out of principle in spite
of the damage to their political futures.
The immortal words of 19th Century
Sen. Daniel Webster, one of the men pro-
filed, rings true today:
“I shall stand by the Union ...with abso-
lute disregard of personal consequences
... Let the consequences be what they they
will, I am careless. No man can suffer too
much, and no man can fall too soon, if he
suffer or if he fall in defense of the liber-
ties and Constitution of his country.”
–The Tennesseean, Nashville
Editorial
When a woman finds a lump in
her breast, her doctor’s first move
is usually to recommend a biopsy –
that is, to remove a small portion of
the lump for analysis. If the lump
is cancerous, doctors test for three
different clinical markers: estrogen
receptor, progesterone receptor and
human epidermal growth factor re-
ceptor. The results determine what
kind of hormone or growth factor
receptor treatment the patient re-
ceives.
About 15-20 percent of breast
cancers, though, don’t test posi-
tive for any of the three markers.
They’re called triple negative breast
cancers, and they’re big trouble.
Treatments developed for cancers
that test positive for any of the three
different markers will not work on
triple negative breast cancers.
Triple negative breast cancers are
more aggressive and more likely to
spread throughout the body.
At the recent International Triple
Negative Breast Cancer Conference
in Atlanta, I presented findings that
show promise of improving treat-
ment and outcomes for some wom-
en with the disease, even though
more study is needed to confirm
my findings.
The five-year survival rate for
women with triple negative breast
cancer is lower – 77 percent – than
the five-year survival rate – 93 per-
cent – for women whose cancers
have one of the three receptors.
Also, because there are no hor-
mone-targeted treatments for triple
negative breast
cancer, women
often must en-
dure
harsher
treatments like
radiation
and
chemotherapy.
Black women
are about three
times
more
likely than white
women to devel-
op triple nega-
tive breast can-
cer, a difference
that could be due to their genetics.
Most researchers working on
triple negative breast cancers study
the tumor themselves. But my re-
search looked at the disease from
a different angle – the way the pa-
tient’s own body attacks the tumor.
When a woman gets breast can-
cer, her immune system leaps into
gear. Her body sends tumor infil-
trating lymphocytes to target and
kill the tumor cells.
Researchers and I looked at 103
early-stage patients with triple neg-
ative breast cancer, 71 of themAfri-
can-American and the rest Europe-
an-American, to see whether there
was a difference in tumor-infiltrat-
ing lymphocyte count. Tumor-infil-
trating lymphocytes were evaluated
in hemotoxylin- and eosin-stained
tissue sections according to the
International TILs Working Group
2014 guidelines by pathologists we
collaborate with at Emory Univer-
sity Hospital. We found that theAf-
rican-Americans had a significantly
higher level of tumor infiltrating
lymphocytes in early-stage cancer
than white women.
We also found higher tumor infil-
trating lymphocyte levels in early-
stage African-American patients
who were diagnosed at a young age
or tested negative for a fourth com-
mon clinical marker, androgen re-
ceptor. African-American women
are more likely to be diagnosed
with triple negative breast cancer
at younger age and lack androgen
receptor, factors associated with
more aggressive disease, compared
to white women.
Maybe most importantly, we
found that we could use the level
of tumor infiltrating lymphocytes
to predict a greater or lower risk of
death: The more tumor infiltrating
lymphocytes, the better the sur-
vival we found among early-stage
African-American cancer patients.
High levels of tumor infiltrating
lymphocytes also seem to correlate
with higher levels of DNA damage
within the tumor. If this correlation
bears out in further research, doc-
tors could use it to predict response
to DNA repair therapies for a spe-
cific patient.
Finally, our study pointed to the
possibility of an exciting new form
of treatment: adoptive T cell thera-
py. In adoptive T cell therapy, doc-
tors extract immune cells from a pa-
tient and genetically engineer them
to expand the patient’s T cells. The
cells are then infused back into the
patient to improve her anti-tumor
response.
Adoptive cell therapy has already
shown promise in melanoma pa-
tients, and it is currently in clini-
cal trials as a treatment option for
breast cancer patients. From our
research, we already know who
might be most likely to respond to
the treatment: African-American
women, in the early stages of the
disease, whose tumor infiltrating
lymphocyte count is lower than
normal. However, we plan to vali-
date these results in additional pa-
tient cohorts.
Triple negative breast cancer is
a scary disease – aggressive, rap-
id-spreading and insusceptible to
the hormone treatments we use to
target most breast cancers. But our
next key to fighting it might not be
in the tumor at all. It just might be
tumor infiltrating lymphocytes,
those tiny anti-cancer warriors our
own bodies throw into the fray.
- Nikita Wright is a Ph.D. can-
didate in biology at Georgia State
University.
USPS-780-720
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